Publications
Reverse chronological order Satoshi Nagata, PH.D 1) Nagata, S.* and Pastan I. (2009) Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Advanced Drug Delivery Reviews, 61, 977-85, PMCID: PMC2757538, PMID: 19679153. (*co-corresponding author acknowledged) 2) Nagata, S.*, Ise, T. and Pastan I. (2009) Fc receptor-like 3 protein expressed on IL-2 non-responsive subset of human regulatory T cells. The Journal of Immunology, 182, 7518-26, PMCID: PMC2745186, PMID: 19494275. (*corresponding author) 3) Onda, M., Beers, R., Xiang, L., Nagata, S., Wang, Q. and Pastan, I. (2008) An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proceedings of National Academy of Sciences of the United States of America, 105, 11311-6, PMCID: PMC2516223, PMID: 18678888. 4) Matsushita, K., Margulies, I., Onda, M., Nagata, S., Stetler-Stevenson, M. and Kreitman R.J. (2008) Soluble CD22 as a tumor marker for hairy cell leukemia. Blood, 112, 2272-7, PMCID: PMC2532804, PMID: 18596230. 5) Das, S., Hahn, Y., Walker, D., Nagata, S., Willingham, M.C., Peehl, D.M., Bera, T., Lee, B. and Pastan, I. (2008) Topology of NGEP, a prostate specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research, 68, 6306-6312, PMCID: PMC2562772, PMID: 18676855. 6) Ise, T., Das, S., Nagata, S., Maeda, H., Lee, Y., Onda, M., Anver, M.R., Bera, T.K. and Pastan, I. (2008) Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications, 365(4):603-8. Epub 2007 Nov 9, PMCID: PMC2189737, PMID: 17996727. 7) Du, X.*, Nagata, S.*, Ise, T., Stetler-Stevenson, M. and Pastan, I. (2008) FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia and B-cell non-Hodgkin’s lymphoma as a target of immunotoxins. Blood 111, 338-343. Epub 2007 Sep 25, PMCID: PMC2200816, PMID: 17895404. (*equal contribution acknowledged) 8) Das, S., Ise, T., Nagata S., Maeda, H., Bera, T.K. and Pastan, I. (2007) Palmitoylation of POTE family proteins for plasma membrane targeting. Biochemical and Biophysical Research Communications, 363(3):751-6. Epub 2007 Sep 21., PMCID: PMC2170890, PMID: 17904529. 9) Kamogae, M., Hashimoto, E.M., Millet, A.P., Francabandiera, A.I., Bracarense, A.P.F.R.L., Bittencourt-Oliveira, M.D., Colus , I.M.D., Itano, E.N., Kawamura, O., Tsutsumi, T., Nagata, S., Harada, K-I., Ueno, Y. and Hirooka, E.Y. (2007) Imunohistochemistry: detection of microcystin in tilápia expose to Microcystis aeruginosa (Cyanobacteria) extract. Semina: Ciencias Agrarias, Londrina 26, 427-436. (in Portuguese) 10) Das, S., Hahn, Y., Nagata, S., Willingham, M.C., Bera, T.K., Lee, B. and Pastan, I. (2007) NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Research 67, 1594-1601, PMID: 17308099. 11) Ise, T.*, Nagata, S.*, Kreitman, R.J., Wilson, W.H., Wayne, A.S., Stetler-Stevenson, M., Bishop, M.R., Scheinberg, D.A., Rassenti, L., Kipps, T.J., Kyle, R.A., Jelinek, D.F., Pastan, I. (2007) Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Leukemia 21, 169-174, PMID: 17051241. (*equal contribution acknowledged) 12) Lee, Y., Ise, T., Ha, D., Saint, F.A., Hahn, Y., Liu, X.F., Nagata, S., Lee, B., Bera, T.K. and Pastan, I. (2006) Evolution and expression of chimeric POTE-actin genes in the human genome. Proceedings of National Academy of Sciences of the United States of America 103, 17885-17890., PMCID: PMC1693842, PMID: 17101985. 13) Onda, M.*, Nagata, S.*, FitzGerald, D.J., Beers, R., Fisher, R.J., Vincent, J.J., Lee, B., Nakamura, M., Hwang, J., Kreitman, R.J., Hassan, R. and Pastan, I. (2006) Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. The Journal of Immunology 177, 8822-8834, PMID: 17142785. (*equal contribution acknowledged) 14) Kamogae, M., Hashimoto, H., Padua, C.G., Soares, F.S., Brancarense, A.P.F.L., Yabe, M.J.S., Ono, E.Y.S., Bittencourt-Oliverira, M.C., Sant’ana, C.L., Tsutsumi, T., Nagata, S., Ueno, Y., Harada, K-I, and Hirooka, E.Y. (2006). Monitoring microcystin and physicochemical parameters: Role of agricultural–aquaculture activity in the water quality. In: Mycotoxins and phycotoxins Advances in determination, toxicology and exposure management edited by: (Henry Njapau, Socrates Trujillo, Hans van Egmond and Douglas Park Eds), ISBN978-90-8686-007-4, Wageningen Academic, Mike Jacobs, p321-332. 15) Onda, M., Nagata, S., Ho, M, Bera, T.K., Hassan, R., Alexander, R.H. and Pastan, I. (2006) Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothlioma. Clinical Cancer Research 12, 4225-4231., PMID: 16857795. 16) Ho, M., Nagata, S., and Pastan, I. (2006) Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proceedings of National Academy of Sciences of the United States of America, 103, 9637-9642., PMCID: PMC1480459, PMID: 16763048. 17) Ise, T., Kreitman, R.J., Pastan, I., and Nagata, S.* (2006) Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. Clinical Chemistry Labiratory Medicine, 44, 594-602. (*corresponding author), PMID: 16681430. 18) Egland, K.A., Liu, X.F., Squires, S., Nagata, S., Man, Y.G., Bera, T.K., Onda, M., Vincent, J.J., Strausberg, R.L., Lee, B, and Pastan, I. (2006) High expression of a cytokeratin-associated protein in many cancers. Proceedings of National Academy of Sciences of the United States of America 103, 5929-5934., PMCID: PMC1458675, PMID: 16585525. 19) Onda, M., Willingham, M., Nagata, S., Bera, T.K., Beer, R., Ho, M., Hassan, R., Kreitman, R.J. and Pastan, I. (2005) New monoclonal antibodies to mesothelin useful for immunohistochemistry, FACS, Western blotting and ELISA. Clinical Cancer Research 11, 5840-5846., PMID: 16115924. 20) Nagata, S., Ise, T., Onda, M., Nakamura, K., Ho, M., Raubitschek, and Pastan, I. (2005) Cell membrane-specific epitopes on CD30: potentially superior targets for immunotherapy. Proceedings of National Academy of Sciences of the United States of America, 102, 7946-7951., PMCID: PMC1142388, PMID: 15905329. 21) Soler-Garcia, A.A., Maitra R., Kumar, V., Ise, T., Nagata, S., Beers, R., Bera, T.K. and Pastan, I. (2005) The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sparm-associated protein. Reproduction 129, 515-524., PMID: 15798027. 22) Bang, S., Nagata, S., Onda, M., Kreitman, R.J. and Pastan, I. (2005) HA22 (R490A) is a recombinant immunotoxin with increased anti-tumor activity without an increase in animal toxicity. Clinical Cancer Research 11, 1545-1550., PMID: 15746059. 23) Ise, T., Maeda, H., Santora, K., Xiang, L., Kreitman, R.J., Pastan, I. and Nagata, S. (2005) IRTA2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. Clinical Cancer Research 11, 87-96., PMID: 15671532. 24) Shibata, H., Yoshioka, Y., Ikemizu, S., Kobayashi, K., Yamamoto, Y., Mukai, Y., Okamoto, T., Taniai, M., Kawamura, M., Abe, Y., Nakagawa, S., Hayakawa, T., Nagata, S., Yamagata, Y., Mayumi, T., Kamada, H., and Tsutsumi, Y. (2004) Functionalization of TNF-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clinical Cancer Research 10, 8293-8300., PMID: 15623605. 25) Nagata, S., Numata, Y., Onda, M., Ise, T., Hahn, Y., Lee, B. and Pastan, I. (2004) Rapid grouping of monoclonal antibodies based on their topographical epitopes by a label-free competitive immunoassay. Journal of Immunological Methods 292, 141-155., PMID: 15350519. 26) Nagata, S. (2004) Production of antibodies (polyclonal antibodies and monoclonal antibodies), in: methods for intracellular signal transduction (Fukui, Y. Ed), ISBN4-7622-3021-9, Japan Scientific Societies Press, Tokyo. p.141-160. (in Japanese) 27) Maeda, H., Nagata, S., Wolfgang, C.D., Bratthauer, G.L., Bera, T.K. and Pastan, I. (2004) The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localizing in mitochondria. The Journal of Biological Chemistry 279, 24561-24568., PMID: 15150260. 28) Yoshioka, Y., Tsutsumi, Y., Ikemizu, S., Yamamoto, Y., Shibata, H., Nishibata, T., Mukai, Y., Okamoto, T., Taniai, M., Kawamura, M., Abe, Y., Nakagawa, S., Nagata, S., Yamagata, Y. and Mayumi, T. (2004) Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency. Biochemical and Biophysical Research Communications 315, 808-814., PMID: 14985084. 29) Nagata, S., Salvatore, G. and Pastan, I. (2003) DNA-immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins., Journal of Immunological Methods 280, 59-72., PMID: 12972188. 30) Yamamoto, Y., Tsutsumi, Y., Yoshioka, Y., Nishibata, T., Kobayashi, K., Okamoto, T., Mukai, Y., Shimizu, T., Nakagawa, S., Nagata, S. and Mayumi, T. (2003) Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity, Nature Biotechnology 21, 546-552., PMID: 12665803. 31) Kamada, H., Tsutsumi, Y., Sato-Kamada, K., Yamamoto, Y., Yoshioka, Y., Okamoto, T., Nakagawa, S., Nagata, S. and Mayumi, T. (2003) Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application as renal targeting carrier. Nature Biotechnology 21, 399-404., PMID: 12612587. 32) Kamogae, M., Tsutsumi, T., Nagata, S., Aymoto, N.M., Ueno, Y. and Hirooka, E.Y. (2002) Monitoring of Microcystins in Fresh Water for Human Consumption in the Itaipu Dam, Parana-Brazil. Brazilian Journal of Food Technology 5, 109-116. (in Portuguese) 33) Nagata, S., Onda M., Numata Y., Santora K., Beers R., Kreitman R.J. and Pastan I. (2002) Novel Anti-CD30 Recombinant Immunotoxins Containing Disulfide-stabilized Fv Fragments. Clinical Cancer Research 8, 2345-2355., PMID: 12114439. 34) Salvatore, G., Nagata, S., Billaud, M., Santoro, M., Vecchio, G. and Pastan I. (2002) Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. Biochemical and Biophysical Research Communications 294, 813-817., PMID: 12061779. 35) Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki, N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y. and Jessberger, R. (2002) SWAP-70 is a guanine-nucleotide-exchange factor that mediates signaling of membrane ruffling. Nature 416, 759-763., PMID: 11961559. 36) Weller, M.G., Zeck, A., Eikenberg, A., Nagata, S., Ueno, Y. and Niessner, R. (2001) Determination of microcystins by an immunoassay of broad specificity. Analytical Sciences 17, 1445-1448., PMID: 11783797. 37) Yoshida, T., Takeda, M., Tsutsumi, T., Nagata, S., Yoshida, F., Harada, T., Maita, K. and Ueno, Y. (2001) Tumor necrosis factor-a expression and Kupffer cell activation in hepatotoxicity caused by microcystin-LR in mice. Journal of Toxicologic Pathology 14, 259-265. 38) Yoshida, T., Tsutsumi, T., Nagata, S., Yoshida, F., Harada, T., Maita, K. and Ueno, Y. (2001) Quantitative analysis of intralobular distribution of microcystin-LR in the mouse liver. Journal of Toxicologic Pathology 14, 205-212. 39) Yoshida, T., Nakamura, Y, Tsutsumi, T., Nagata, S., Yoshida, F., Harada, T., Maita, K. and Ueno, Y. (2001) Transmission electron and immunoelectron microscopic studies on microcystin-LR-induced hepatic injuries in mice. Journal of Toxicologic Pathology 14, 157-161. 40) Onda, M., Nagata, S., Tsutsumi, Y., Vincent, J.J., Wang, Q., Kreitman, R.J., Lee, B. and Pastan I. (2001) Lowering the Isoelectric Point of the Fv Portion of Recombinant Immunotoxins Leads to Decreased Nonspecfic Animal Toxicity without Affecting Antitumor Activity. Cancer Research 61, 5070-5077., PMID: 11431343. 41) Nagata, S. (2001) Recombinant immunotoxin for cancer therapy: current status and prospective. Tanpakushitsu Kakusan Koso 46, 540-546. (in Japanese), PMID: 11268658. 42) Onda, M., Willingham, M., Wang, Q., Kreitman, R.J., Tsutsumi, Y., Nagata, S., Dinarello, C.A. and Pastan, I. (2000) Inhibition of TNF alpha Produced by Kupffer’s Cells Protects against the Non-Specific Liver Toxicity of Immunotoxin Anti-Tac(Fv)-PE38, LMB-2. The Journal of Immunology 15, 7150-7156., PMID: 11120846. 43) Nishio, Y., Nagata, S., Umeda, M., Shirai, R., Yokogawa, T., Ihara, S. and Fukui Y. (2000) Quantification of Phosphatidylinositol 3,4,5-Trisphosphate by Liposome Lysis Assay with Specific Monoclonal Antibodies. Analytical Biochemistry 285, 270-273., PMID: 11017714. 44) Tsutsumi, T., Nagata, S., Yoshida, F. and Ueno, Y. (2000) Development and application of highly sensitive anti-immune complex ELISA for microcystins in tap water. Food and Agricultural Immunology 12, 231-241. 45) Tsutsumi, T., Nagata, S., Hasegawa, A. and Ueno Y. (2000) Immunoaffinity column as clean-up tool for determination of trace amounts of microcystins in tap water. Food Chemistry and Toxicology 38, 593-597., PMID: 10942320. 46) Tsutsumi, Y., Onda, M., Nagata, S., Lee, B., Kreitman, R.J. and Pastan, I. (2000) Site-specific chemical modification with polyetylene glycol of rcombinant immunotoxin anti-Tac (Fv)-PE38 (LMB2) improves anti-tumor activity and reduces animal toxicity and immunogenicity, Proceedings of National Academy of Sciences of the United States of America 97, 8548-8553., PMCID: PMC26985, PMID: 10890891. 47) Yokogawa, T., Nagata, S., Nishio, Y., Tsutsumi, T., Ihara, S., Shirai, R., Morita, K., Umeda, M., Shirai, Y., Saitoh, N. and Fukui, Y. (2000) Evidence that 3'-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P(2), FEBS Letter 473, 222-226., PMID: 10812079. 48) Nagata, S., Tsutsumi, T., Yoshida, F. and Ueno, Y. (1999) A new type sandwich immunoassay for microcystin: Production of monoclonal antibodies specific to the immune complex formed by microcystin and an anti-microcystin monoclonal antibody, Natural Toxins 7, 49-55., PMID: 10495466. 49) Kobayashi, M., Nagata, S., Iwasaki, T., Yanagihara, K., Saitoh, I., Ihara, S. and Fukui, Y. (1999) Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase, Proceedings of National Academy of Sciences of the United States of America 96, 4874-4879., PMCID: PMC21784, PMID: 10220386. 50) Tanaka, K., Horiguchi, K., Yoshida, T., Takeda, M., Fujisawa, H., Takeuchi, K., Umeda, M., Kato, S., Ihara, S., Nagata, S. and Fukui, Y. (1999) Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus., The Journal of Biological Chemistry 274, 3919-3922., PMID: 9933577. 51) Tanaka, K., Adachi, H., Konishi, H., Iwamatsu, A., Ohkawa, K., Shirai, T., Nagata, S., Kikawa U., and Fukui, Y. (1999) Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-triphosphate binding protein in Dictyostelium discrauitems. Bioscience Biotechnology and Biochemistry 63, 368-372., PMID: 10192918. 52) Ueno, Y., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Tamura, S, Sekijima, M., Tashiro, F., Harada, T. and Yoshida, T. (1999) No choronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial haeptotoxion, in female Balb/C mice. Environmental toxicology 14, 45-55. 53) Fukui, Y., Ihara, S. and Nagata, S. (1998) Downstream of phosphatidylinositol 3-kinase, a multifunctional signaling molecule, and its regulation in cell responses. Journal of Biochemistry 124, 1-7., PMID: 9644237. 54) Shirai, T., Tanaka, K., Terada, Y., Sawada, T., Shirai, R., Hashimoto, Y., Nagata, S., Iwamatsu, A., Okawa, K., Li, S. Hattori, S., Mano, H. and Fukui, Y. (1998) Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: An application for rapid purification of the PIP3 binding proteins. Biochimica et Biophysica Acta, 1402, 292-302., PMID: 9606988. 55) Yoshida, Y., Tsutsumi, T., Makita, Y., Nagata, S., Tashiro, F., Yoshida, F., Sekijima, M., Shin-ichi, T., Harada, T., Keizo, M. and Ueno, Y. (1998) Immunohistochemical localization of microcystin-LR in the liver of mice: a study on pathogenesis of microcystin-LR-induced hepatotoxicity. Toxicologic Pathology, 26, 411-418., PMID: 9608648. 56) Tsutsumi, T., Nagata, S., Yoshida, F. and Ueno, Y. (1998) Anti-idiotype monoclonal antibodies against anti-microcystin antibody and its use in enzyme immunoassay. Toxicon, 36, 235-245., PMID: 9620572. 57) Kita, Y., Kimura, D.K., Kobayashi, M., Ihara, S., Kaibuchi, K., Kuroda, S., Ui, M., Iba, H., Konishi, H., Kikkawa, U., Nagata, S. and Fukui, Y. (1998) Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway. Journal of Cell Science, 111, 907-915., PMID: 9490635. 58) Tsutsumi, T., Nagata, S., Yoshida, F. and Ueno, Y. (1998) Development of sandwich immunoassay for microcystins, a natural contaminant in environmental water: an assay based on anti-immune complex antibodies. Japanese Journal of Toxicology and Environmental Health, 44, 25-25. 59) Daduang, S., Kimura, K., Nagata, S. and Fukui, Y. (1998) Density dependent elevation of phosphatidylinositol-3 kinase level in rat 3Y1 cells. Biochimica et Biophysica Acta, 1401, 113-120. PMID: 9459491. 60) Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T. and Fukui, Y. (1997) Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. The EMBO Journal, 16, 5345-5352., PMCID: PMC1170166, PMID: 9311994. 61) Ichiba, T., Kuraishi, Y., Sakai, O., Nagata, S., Groffen, J., Kurata, T., Hattori, S. and Matsuda, M. (1997) Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2. The Journal of Biological Chemistry, 272, 22215-22220., PMID: 9268367. 62) Yoshida, T., Makita, Y., Nagata, S., Tsutsumi, T., Yoshida, F., Sekijima, M., Tamura, S. and Ueno, Y. (1997) Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice. Natural Toxins, 5, 91-95., PMID: 9285911. 63) Kobayashi, M., Nagata, S., Kita Y., Nakatsu, N., Ihara, S., Kaibuchi, K., Kuroda, S., Ui, M., Iba, H., Konishi, H., Kikkawa, U., Saitoh, I. and Fukui, Y. (1997) Expression of a constitutively active phosphatidylinositol-3 kinase induces process formation in rat PC12 cells: use of cre-loxP recombination system. The Journal of Biological Chemistry, 272, 16089-16092., PMID: 9195902. 64) Tanaka, K., Ohmi, S., Sawada, T., Shirai, R., Hashimoto, Y., Iwasaki, S., Kaibuchi, K., Kanaho, Y., Shirai, T., Terada, Y., Kimura, K., Nagata, S. and Fukui, Y. (1997) A target of phosphatidylinositol-3,4,5-trisphosphate with a zinc finger motif homologous to ARF GTPase activating protein and two PH domains: Two essential PH domains for binding to phosphatidylinositol-3,4,5-trisphosphate. European Journal of Biochemistry, 245, 512-519., PMID: 9151987. 65) Nagata, S., Tsutsumi, T., Hasegawa, A., Yoshida, F., Ueno, Y. and Watanabe, M.F. (1997) Enzyme immunoassay for direct determination of microcystins in environmental water. Journal of Association of Official Analytical Chemists, 80, 408-417. 66) Ueno, Y., Nagata, S., Tsutsumi, T., Hasegawa, A., Yoshida, F., Sutajjit, M., Mebs, D. and Vasconcelos, V. (1996) Survey of microcystins in environmental water by a highly sensitive immunoassay based on monoclonal antibody. Natural Toxins, 4, 271-276., PMID: 9029552. 67) Kondo, F., Matsumoto, H., Yamada, S., Ishikawa, N., Ito, E., Nagata, S., Ueno, Y., Suzuki, M. and Harada, K. (1996) Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers. Chemical Research in Toxicology, 9, 1355-1359., PMID: 8951240. 68) Senpuku, H., Iizima, T., Yamaguchi, Y., Nagata, S., Ueno, Y., Saito, M., Hanada, N. and Nisizawa, T. (1996) Immunogenicity of peptides coupled with multiple T-cell epitopes of a surface protein antigen of Streptococcus mutants. Immunology, 88, 275-283., PMID: 8690461. 69) Ueno, Y., Nagata, S., Hasegawa, A., Tsutsumi, T., Watanabe, M.F., Ho-Dong, P., Chen, G.-C., Chen, G. and Yu, S.-Z. (1996) Detection of microcystins, a blue-green algal tumor promoter, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive Immunoassay. Carcinogenesis, 17, 1317-1321., PMID: 8681449. 70) Ueno, Y., Umemori, K., Niimi, E., Tanuma, S., Nagata, S., Kobayashi, M., Sugamata, M., Ihara, T., Sekijima, M., Kawai, K., Ueno, I. and Tashiro, F. (1995) Induction of apoptosis by T-2 toxin and related natural toxins in HL-60 human promyelotic leukemia cells. Natural Toxins, 3, 129-137., PMID: 7648021. 71) Hashimoto, E. H., Kamogae, M., Vanzella, T. P., Colus, . M. S., Bracarense, A.P.F.R.L., Bittencourt-Oliveira, M.C., Itano, E., Kato, H., Kuroda, E. K., Nagata, S., Ueno, Y., Harada, K-I, Hirooka, E.Y. (2010) Biomonitoring of Microcystin and Aflatoxin Co-occurrence in Aquaculture using Immunohistochemistry and Genotoxicity Assays – Micronucleus and Comet Assay. Toxicon, in press 72) Daduang S., Nagata, S., Matsuda, M., Yamori, T., Onodera, K. and Fukui, Y. (1995) Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85., Immunology and Cell Biology, 73, 134-139., PMID: 7541019. 73) Nagata, S., Tsutsumi, T., Hasegawa, A., Watanabe, M.F. and Ueno, Y. (1995) Determination of microcystin in environmental water by highly sensitive immunoassay., Japanese Journal of Toxicology and Environmental Health, 41, 10-10. 74) Ueno, Y. and Nagata, S. (1994) Natural Poisons (1) Algae toxin, The Journal of Toxicological Sciences, 19, Appendix 75-84. (in Japanese) 75) Nagata, S., Soutome, H., Tsutsumi, T., Hasegawa, A., Sekijima, M., Sugamata, M., Harada, K., Suganuma, M. and Ueno, Y. (1995) Novel monoclonal antibodies against microcystin and their protective activity to the hepatotoxicity., Natural Toxins, 3, 78-86., PMID: 7613739. 76) Matsumura, S., Ishida, T., Washizu, T., Tomoda, I., Nagata, S., Chiba, J. and Kurata, T. (1993) Pathologic features of acquired immunodeficiency-like syndrome in cats experimentally infected with feline immunodeficiency virus., The Journal of Veterinary Medical Science, 55, 387-394., PMID: 8395225. 77) Tanaka, S., Matsuda, M., Nagata, S., Kurata, T., Nagashima, K., Shizawa, Y. and Fukui, Y. (1993) Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies., Japanese Journal of Cancer Research, 84, 279-289., PMID: 7683636. 78) Matsuda, M., Nagata, S., Tanaka, S., Nagashima, K. and Kurata, T. (1993) Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins: Evidence from reactivity to monoclonal antibodies. The Journal of Biological Chemistry, 268, 4441-4446., PMID: 7680038. 79) Nagata, S., Okamoto, Y., Inoue, T., Ueno, Y., Kurata, T. and Chiba, J. (1992) Identification of epitopes associated with different biological activities on the glycoprotein of vesicular stomatitis virus by use of monoclonal antibodies. Archives of Virology, 127, 153-168., PMID: 1280941. 80) Matsuda, M., Tanaka, S., Nagata, S., Kojima, A., Kurata, T. and Sibuya, M. (1992) Two species of human CRK cDNA encode proteins with distinct biological activities. Molecular and Cellular Biology, 12, 3482-3489., PMCID: PMC364597, PMID: 1630456. 81) Nagata, S., Kurata, T., Ueno, Y. and Chiba, J. (1991) Vesicular stomatitis virus-mediated cell fusion subsequent to virus adsorption at different pH values. Japanese Journal of Medical Science and Biology, 44, 171-180., PMID: 1668239. 82) Nagata, S., Yamamoto, K., Ueno, Y., Kurata, T. and Chiba, J. (1991) Preferential generation of monoclonal IgG-producing hybridomas by use of vesicular stomatitis virus-mediated cell fusion. Hybridoma, 10, 369-378., PMID: 1655635. 83) Nagata, S., Yamamoto, K., Ueno, Y., Kurata, T. and Chiba, J. (1991) Production of monoclonal antibodies by the use of pH-dependent vesicular stomatitis virus-mediated cell fusion. Hybridoma, 10, 317-322., PMID: 1651903. Tomoko Ise, M.D., Ph.D 2. Shimizu T, Lee EL, Ise T, Okada Y. Volume-sensitive Cl(-) channel as a regulator of acquired cisplatin resistance. Anticancer Res., 28, 75-83, 2008 3. Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia and B-cell non-Hodgkin’s lymphoma as a target of immunotoxins. Blood, 111, 338-343, 2008 4. Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I. 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