Microarray Data

This is the data is the full data set that appeared in the following publications:

Annotated Genes

Unknown Genes

Chattopadhyay, S., Ito, M., Cooper, J. D., Brooks, A. I., Curran, T. M., Powers, J. M. and Pearce, D. A. (2002). An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegeneartive disorder Batten disease. Hum. Mol. Genet. 11 , 1421-1431.

Bijlani, R., Chen, Y., Brooks, A. I., Pearce D. A. and Ogihara, M. (2002). Prediction of biologically significant components from microarray data: Independently Consistent Expression Discriminator (ICED). Bioinformatics. 19, 62-70.

Brooks, A. I, Chattopadhyay, S, Mitchison, H. M, Nussbaum, R. L and Pearce, D.A. (2003). Functional Categorization of Gene Expression Changes in the Cerebellum of a Cln3-Knockout Mouse Model for Batten Disease. Mol. Gen Metab. 78, 17-30.

 This is the data is the full data set that appeared in the following publication:

Results from 10 week old whole brain cln1- and cln3-knockout mice > 1-5 fold change, pvalue < 0.05

Gene expression changes in the whole brain of cln1-knockout mice < 1-5 fold change, pvalue <0.05.

Gene expression changes in the whole brain of cln3-knockout mice < 1-5 fold change, pvalue <0.05.

Elshatory, Y, Brooks, A. I, Chattopadhyay, S, Curran, T. M, Gupta, P, Ramalingam, V, Hofmann, S. L. and Pearce, D. A. (2003). Early Changes in Gene Expression in Two Models of Batten Disease. FEBS Lett. 538, 207-212.

This is the data is the full data set that appeared in the following publication:

Eye-array, all changes (Table 1)

Eye-array, changes specific to eye (Table 2)

Chattopadhyay, S., Kingsley, E., Serour, A., Curran, T. M., Brooks, A. I., and Pearce, D. A. (2004). Altered Gene Expression in the Eye of a Mouse Model for Batten Disease. IOVS. 45, 2893-2905.